Physics for BNCT

Translational Research on BNCT for Clinical Application

Background and Objective Using Kyoto University Research Reactor (KUR), patients with malignant tumors greater than 500 have been treated with boron neutron capture therapy (BNCT). Malignant brain tumors and head and neck cancers have been main malignancies treated with BNCT. Our laboratory (Division of Particle Radiation Oncology) has investigated the possibilities for new applications for BNC...

Clinical Requirements and Accelerator Concepts for Bnct

Accelerator-based neutron sources are an attractive alternative to nuclear reactors for providing epithermal neutron beams for Boron Neutron Capture Therapy. Based on clinical requirements and neutronics modeling the use of proton and deuteron induced reactions in 7Li and 9Be targets has been compared. Excellent epithermal neutron beams can be produced via the 7Li(p,n)7Be reaction at proton ene...

Epithermal Neutron Beam Generator Design for Bnct

BNCT is a radiotherapy modality based on the neutron capture and fission reactions that occur when boron-10 is irradiated by thermal neutrons. This reaction generates alpha and lithium that produce high density of ionizations in close to the reaction site. The concept provides high absorbed doses into the cancerous cells preserving the adjacent healthy tissues. Nowadays, the available neutron s...

Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma: comparison of clinical results obtained with BNCT and conventional treatment.

The purpose of this study was to evaluate the clinical outcome of boron neutron capture therapy (BNCT) and conventional treatment in patients with newly diagnosed glioblastoma. Since 1998 we treated 23 newly-diagosed GBM patients with BNCT without any additional chemotherapy. Their median survival time was 19.5 months; the 2-, 3-, and 5-year survival rates were 31.8%, 22.7%, and 9.1%, respectiv...

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